Interstitial
Cystitis: A Comprehensive Overview
Also known as
painful bladder syndrome, Interstitial Cystitis (IC) is a chronic disorder
causing pain and discomfort for many people, oftentimes impeding normal
life. Though a malady affecting both
sexes, females are much more likely to suffer from the condition. Recent studies
report an IC incidence rate of 197 diagnoses in women per 100,000 compared to
41 diagnoses in men per 100,000.1 Perhaps the numbers appear at
first to be negligible in the grand scheme of things, yet this disease can be
life-altering.
Symptomatology
As the name
implies, IC is an uncomfortable affliction, causing symptoms such as bladder
pressure and pain, bladder urgency with little output, painful intercourse, as
well as pelvic pain and discomfort. Ranging from mild to severe, the pain can
significantly impair everyday activities such as social engagements, exercise,
sleep and the ability to perform job duties.2, 3 Further, many
people experience flare-ups due to triggering events such as menstruation,
stress, exercise and extended periods of sitting.2
Diagnosis
Oftentimes
difficult to diagnose, doctors frequently attempt to rule out other illnesses
with similar symptom profiles such as kidney stones, bladder cancer, sexually
transmitted diseases, endometriosis, inflamed prostate, chronic pelvic pain
syndrome and infection before looking further into the possibility of an IC
diagnosis.2 Frequently, IC symptoms may mirror signs of a chronic
urinary tract infection but generally no infection is present in those
suffering from this condition.2, 3 If, however, an IC patient does contract
a urinary infection, symptoms are oftentimes heightened.3 In
addition, most experts agree that due to IC’s wide range of symptoms and
intensity of pain and discomfort, that IC may actually be a combination of
multiple diseases.2 Further complicating the diagnostic process is
the fact that not only are many family physicians lacking in knowledge in
regard to IC but there often tend to be multiple comorbidities with it as well.4,
5 These factors oftentimes present symptom-overlap and subsequent
misdiagnoses which will be discussed shortly.4, 5
Though IC is
predominantly observed and diagnosed during middle age (average age of onset 40
years), both men and women can see the emergence of the disorder between the
ages of 20 and 50.6 As mentioned previously, IC is much more common
in females than males due to the shorter length of the urethra in women.7
Because of this difference in anatomy, bacteria has an easier method of
reaching the bladder and becoming overpopulated, thus causing inflammation.2,
7
IC can be
categorized several different ways. Oftentimes it is divided into two
phenotypes, non-ulcerative and ulcerative.8 Non-ulcerative IC
accounts for approximately 90% of patients with the disorder and is typically
identified by the observance of pinpoint hemorrhages in the bladder wall
(indicating bladder inflammation is present).8 Ulcerative IC
comprises 5-10% of IC patients and is identified when patients present with
Hunner’s ulcers (red, bleeding areas) on the bladder wall.8 End
stage or severe IC has also been used as a classification of the disorder,
referring to patients who have developed very hard bladders as well as low
bladder capacity and excruciating pain.8
IC is also
sometimes identified as being uncomplicated and complicated in nature.7 Uncomplicated
IC is characterized by symptoms contained within the lower urinary tract as
well as the absence of risk factors for severe infection or long-term
impairment.7 Further, uncomplicated IC is typically easily treatable
and eliminated without much difficulty.7 In contrast, complicated IC typically
does not respond to antibiotic treatment, may present an increased risk of
infection, possible spreading of infection to the kidneys, and inflammation of
the renal pelvis (pyelonephritis).7 Particular populations are at
greater risk for complicated IC including those with compromised immune
systems, kidney problems or who demonstrate anatomical abnormalities in the
urinary tract.7
Diagnostic tests
for IC include urine samples to test for bacteria, white and red blood cells,
proteins and nitrites (can be an indicator of bacteria); ultrasound to examine
the kidneys and bladder; and in rare cases, cystoscopy or x-ray (only used when
a woman has severe and recurrent symptoms).7 Additional tests that are
less common but sometimes performed include bladder and urethra biopsy, bladder
stretching and in men, prostate fluid culture.2
References
1. Arora HC, Shoskes DA. The enigma of men with interstitial cystitis/bladder pain syndrome. Translational Andrology and Urology. 2015;4 (6): 668-676.
2. WebMD.
Interstitial Cystitis. Available at: https://www.webmd.com/urinary-incontinence-oab/interstitial-cystitis#1.
Accessibility verified July 6, 2018.
3. Mayo
Clinic. Interstitial Cystitis. Available at: https://www.mayoclinic.org/diseases-conditions/interstitial-cystitis/symptoms-causes/syc-20354357.
Accessibility verified July 6, 2018.
4. Clemens
JQ, Calhoun EA, Litwin MS, et al. A survey of primary care physician practices
in the diagnosis and management of women with interstitial cystitis/ painful
bladder syndrome. Urology. 2010; 76(2): 323-328.
5. American
Urological Association. First-ever clinical guidance on interstitial
cystitis/bladder pain Syndrome Released: Effective treatment includes valid
diagnosis, effective symptom control and focus on quality of life. Available
at: http://auanet.mediaroom.com/2011-03-01-FIRST-EVER-CLINICAL-GUIDANCE-ON-INTERSTITIAL-CYSTITIS-BLADDER-PAIN-SYNDROME-RELEASED.
Accessibility verified July 6, 2018.
6. Harvard
Health Publishing Harvard Medical School: Trusted Advice for a Healthier Life.
Interstitial Cystitis. Available at:
https://www.health.harvard.edu/diseases-and-conditions/interstitial-cystitis.
Accessibility verified July 6, 2018.
7. PubMed
Health. Cystitis: overview. Available at:
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072587/. Accessibility verified
July 6, 2018.
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