There does not
appear to be much debate when discussing the importance of nutrition on patients
suffering from wounds and burns and likewise with people who are HIV positive. More
specifically, increased intake of protein is often posed as the essential
nutrient for such patients. However, as is always the case, it is of paramount
importance to examine the scientific findings of such claims before making the
assumption that the recommendations are sound. For the purposes of this paper,
a brief review of the literature concerning the afore-mentioned populations in
relation to protein intake will be presented.
Wound and Burn Healing
According to an
article published in the British Journal of Nursing, author Linda Russell
reported that protein deficiency poses many detriments to the healing process
such as reduction in collagen formation.1 Further, Russell commented
that high exudate loss has the potential to deplete protein stores by 100 grams
per day, thus indicating the need for heightened intake of protein.1 It
should be noted that in addition to increased protein intake, the author
encouraged a comprehensive evaluation of nutrition overall, stating that a
holistic approach to nutrient load is vital to wound healing.1
A 2014 review of
the literature looked at the necessity of nutrition, including the subset of
protein, in relation to wound healing.2 Researchers stated that
increased protein needs were noted as a
result of protein loss due to large surface area of unhealed wounds, wound
exudates, chronic wound sites, and losses in lean body mass.2, 3
Further, researchers stated that in order to experience wound healing, protein
losses must be accounted for and replaced by increased intake of protein.2
Once again, it is noteworthy to mention that the authors recommend a
comprehensive overview of nutrition and possible supplementation of various
sources to enhance wound healing, rather than solely relying upon increased
protein intake.
In a 1993 study of
28 malnourished patients with truncal pressure ulcers, researchers examined the
effect of protein on wound healing.3 Patients were divided into two
groups, one receiving 24% protein (high intake) and the other receiving 14%
protein (moderately high intake).3 Researchers observed a decrease
in wound surface area in the higher protein group but not the moderate protein
group.3 Higher caloric intake was also noted as a contributing
factor to the reduction in wound surface area in the higher protein group.3
Though the researchers concluded that high protein diets may improve
wound healing, it is important to point out the uniqueness of the population
studied (malnourished nursing home patients) and not automatically apply the
findings to the general population.
A 2009 review of
the literature studied the connection between nutrition and wound healing and
confirmed conclusions previously mentioned. Authors stated, based upon their
review, that protein is a vital
component to wound and burn healing.4 Skin regrowth, according to
the review, is dependent upon cell proliferation and protein synthesis, both of
which require increased protein consumption.4 In addition,
researchers concluded that rapid protein initiation was vital in preventing
protein malnourishment in patients.4 Researchers not only
recommended protein intake increase but also the inclusion of anabolic hormones
to heighten the body’s response to protein4 Of key importance would be an additional review
of the data concerning risks involved with this type of supplementation, a suggestion not examined in the current
article.
A literature
review in the Indian Journal of Critical Care Medicine examined the importance
of hydration and nutritional intake in relation to pressure ulcers.5
Researchers noted that though hydration is of key importance to the
regeneration of skin, nutrition is equally imperative to the wound healing
process.5 Protein, along with a multitude of other nutrients, was
recommended as essential to the process
of wound healing, stating that protein was the most important macronutrient
involved in the repair of tissues.5
In a 2014 Cochrane
Review, researchers studied a variety of factors in regard to wound healing,
including increased protein intake.6 Outcome results showed a lack
of efficacy in regard to the incorporation of increased protein and wound
healing.6 Furthermore, out of the fourteen studies reviewed, authors
concluded that nutritional supplements overall showed no benefit to wound
healing (with the questionable exception of arginine which showed possible but
not convincing efficacy).6
References
1. Russell, L. The importance of patients'
nutritional status in wound healing. British Journal of Nursing. 2013;
10(1): 44-49.
2. Molnar JA, Underdown MJ, Clark
WA. Nutrition and chronic wounds. Advanced Wound Care (New
Rochelle). 2014;3(11):663–681.
3. Breslow RA, Hallfrisch J, Guy
DG, Crawley B, Goldberg AP. The importance of dietary protein in healing
pressure ulcers. Journal of the American Geriatric Society. 1993;
41(4): 357-362.
4. Demling RH. Nutrition,
anabolism, and the wound healing process: an overview. Eplasty. 2009;9:e9.
5. Saghaleini SH, Dehghan K,
Shadvar K, Sanaie S, Mahmoodpoor A, Ostadi Z. Pressure ulcer and nutrition. Indian
Journal of Critical Care Medicine. 2018;22(4):283–289.
6. Langer G, Fink A.
Nutritional interventions for preventing and treating pressure ulcers. Cochrane
Database of Systematic Reviews 2014, Issue 6. Art. No.:CD003216.
DOI: 10.1002/14651858.CD003216.pub2.
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